Nature study: RNA-triggered CRISPR-Cas12a2 selectively kills cancer cells in cell and mouse models
A study published in Nature shows that after the team programmed RNA-guided CRISPR-Cas12a2 to recognize cancer-specific transcripts, it triggered chromatin cleavage, a DNA damage response, and cancer cell death. Secondary reports add p53 mRNA recognition and therapeutic effects in lung and liver cancer mouse models. The three sources collectively confirm the tumor-selective killing potential of this mechanism, but details about the exact target combinations and model settings are not fully consistent across sources, and information not mentioned in a source cannot be confirmed.